AUTISM AND THE SMELL OF FEAR
Odors that carry social cues seem to affect those on the autism spectrum differently
REHOVOT, ISRAEL—November 27, 2017— Autism typically involves the inability to read social cues. We most often associate this with visual difficulty in interpreting facial expression, but new research at the Weizmann Institute of Science suggests that the sense of smell may also play a central role in autism. As reported in Nature Neuroscience, Institute researchers show that people on the autism spectrum have different – and even opposite – reactions to odors produced by the human body. These odors are ones that we are unaware of smelling, but which are, nonetheless, a part of the nonverbal communication that takes place between people, and which have been shown to affect our moods and behavior. Their findings may provide a unique window on autism, including, possibly, on the underlying developmental malfunctions in the disorder.
Researchers in the lab of Prof. Noam Sobel, Department of Neurobiology, investigate, among other things, the smells that announce such emotions as happiness, fear, or aggression to others. Although this sense is not as dominant in humans as it is in many other mammals, we still subliminally read and react to certain odors. For example “smelling fear,” even if we cannot consciously detect its odor, is something we may do without thinking. Since this is a form of social communication, Prof. Sobel and members of his lab wondered whether it might be disrupted in a social disorder like autism.
To conduct their experiments, Prof. Sobel and lab members Yaara Endevelt-Shapira and Ofer Perl, together with others in his lab, devised a series of experiments with a group of participants on the high functioning end of the autism spectrum who volunteered for the study. To begin with, the researchers tested the ability of both autistic and control volunteers to identify smells that can be consciously detected, including human smells like sweat. There was no significant difference between the groups at this stage, meaning the sense of smell in the autistic participants was not significantly different from that of controls.
Two groups were then exposed to either to the “smell of fear” or to a control odor. The smell of fear was sweat collected from people taking skydiving classes, and control odor was sweat from the same people, only this time it had been collected when they were just exercising, without feeling fear.
This is where differences emerged. Although neither group reported detecting dissimilarities between the two smells, their bodies reacted to each in a different way. In the control group, smelling the fear-induced sweat produced measurable increases in the fear response – for example, in skin conductivity – while the everyday sweat did not. In the autistic men, fear-induced sweat lowered their fear responses, while the odor of “calm sweat” did the opposite: it raised their measurable anxiety levels.
Next, the group created talking robotic mannequins that emitted different odors through their nostrils. These mannequins gave the volunteers, who were unaware of the olfactory aspect of the experiment, different tasks to conduct. Using mannequins enabled the researchers to have complete control over the social cues – odor-based or other – that the subjects received. The tasks were designed to evaluate the level of trust that the volunteers placed in the mannequins – and here, too, the behavior of autistic volunteers was the opposite of the control group: they displayed more trust in the mannequin that emitted the fear-induced odor and less in the one that smelled “calmer.”
In continuing experiments, the researchers asked whether other subliminal “social odors” have a different impact in autism than in control groups. In one study, the volunteers were exposed to sudden loud noises during their sessions while simultaneously being exposed to hexadecanal – a potentially calming component of body odor. Another automatic fear response – blinking – was recorded using electrodes above the muscles of the eye. Indeed, the blink response in the control group was weaker when they were exposed to hexadecanal, while for those in the autistic group this response was stronger with hexadecanal.
In other words, the autistic volunteers in the experiment did not display an inability to read the olfactory social cues in smell, but rather they misread them. Prof. Sobel and his group think that this unconscious difference may point to a deeper connection between our sense of smell and early development. Research in recent years has turned up smell receptors like those in our nasal passages in all sorts of other places in our bodies, from our brains to our uteri. It has been suggested that these play a role in development, among other things. In other words, it is possible that the sensing of subtle chemical signals may go awry at crucial stages in the brain’s development in autism. “We are still speculating, at this point,” says Prof. Sobel, “but we are hoping that further research in our lab and others will clarify both the function of these unconscious olfactory social cues and their roots in such social disorders as autism.”
Prof. Noam Sobel’s research is supported by the Azrieli National Institute for Human Brain Imaging and Research, which he heads; the Carl and Micaela Einhorn-Dominic Institute for Brain Research, which he heads; the Nadia Jaglom Laboratory for Research in the Neurobiology of Olfaction; the Adelis Foundation; the late H. Thomas Beck; the Rob and Cheryl McEwen Fund for Brain Research; the Mike Rosenbloom Foundation; and the European Research Council. Prof. Sobel is the incumbent of the Sara and Michael Sela Professorial Chair of Neurobiology.
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The Weizmann Institute of Science in Rehovot, Israel, is one of the world’s top-ranking multidisciplinary research institutions. The Institute’s 3,800-strong scientific community engages in research addressing crucial problems in medicine and health, energy, technology, agriculture, and the environment. Outstanding young scientists from around the world pursue advanced degrees at the Weizmann Institute’s Feinberg Graduate School. The discoveries and theories of Weizmann Institute scientists have had a major impact on the wider scientific community, as well as on the quality of life of millions of people worldwide.